β-Arrestin-mediated receptor trafficking and signal transduction
SK Shenoy, RJ Lefkowitz - Trends in pharmacological sciences, 2011 - cell.com
β-Arrestins function as endocytic adaptors and mediate trafficking of a variety of cell-surface
receptors, including seven-transmembrane receptors (7TMRs). In the case of 7TMRs, β …
receptors, including seven-transmembrane receptors (7TMRs). In the case of 7TMRs, β …
PDZ domains and their binding partners: structure, specificity, and modification
PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …
GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs
Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two
distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction …
distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction …
Protein SUMOylation modification and its associations with disease
Y Yang, Y He, X Wang, Z Liang, G He… - Open …, 2017 - royalsocietypublishing.org
SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …
functions including cell growth, migration, cellular responses to stress and tumorigenesis …
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
Motivation: Sumoylation is a post-translational modification (PTM) process, in which small
ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protein. It is …
ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protein. It is …
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer
C Liu, X Wang, W Qin, J Tu, C Li, W Zhao… - Cancer …, 2023 - Wiley Online Library
Abstract Background Immune checkpoint inhibitors (ICIs) targeting programmed cell death
protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown a moderate …
protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown a moderate …
JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs
G Beauclair, A Bridier-Nahmias, JF Zagury… - …, 2015 - academic.oup.com
Motivation: Post-translational modification by the Small Ubiquitin-like Modifier (SUMO)
proteins, a process termed SUMOylation, is involved in many fundamental cellular …
proteins, a process termed SUMOylation, is involved in many fundamental cellular …
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation
O Boix, M Martinez, S Vidal… - Nature …, 2022 - nature.com
The human transcriptome contains thousands of small open reading frames (sORFs) that
encode microproteins whose functions remain largely unexplored. Here, we show that …
encode microproteins whose functions remain largely unexplored. Here, we show that …
Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis
The covalent attachment of SUMO (small ubiquitin-like modifier) to other intracellular
proteins affects a broad range of nuclear processes in yeast and animals, including …
proteins affects a broad range of nuclear processes in yeast and animals, including …
GPS-SNO: Computational Prediction of Protein S-Nitrosylation Sites with a Modified GPS Algorithm
As one of the most important and ubiquitous post-translational modifications (PTMs) of
proteins, S-nitrosylation plays important roles in a variety of biological processes, including …
proteins, S-nitrosylation plays important roles in a variety of biological processes, including …