Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

[HTML][HTML] COVID-19 and the human innate immune system

JL Schultze, AC Aschenbrenner - Cell, 2021 - cell.com
The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

Sex disparities in COVID-19 severity and outcome: are men weaker or women stronger?

R Pivonello, RS Auriemma, C Pivonello, AM Isidori… - …, 2021 - karger.com
Abstract The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health issue which has …

[HTML][HTML] Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

LYR Wong, J Zheng, K Wilhelmsen, K Li, ME Ortiz… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is especially severe in aged populations.
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …

Age-related risk factors and complications of patients with COVID-19: a population-based retrospective study

H Zhang, Y Wu, Y He, X Liu, M Liu, Y Tang, X Li… - Frontiers in …, 2022 - frontiersin.org
Objective: To study the differences in clinical characteristics, risk factors, and complications
across age-groups among the inpatients with the coronavirus disease 2019 (COVID-19) …

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age

M Humbert, A Olofsson, D Wullimann… - Proceedings of the …, 2023 - National Acad Sciences
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …

Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells

D Zhou, M Borsa, AK Simon - Aging Cell, 2021 - Wiley Online Library
The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …

[HTML][HTML] Tissue-specific immunity for a changing world

SP Weisberg, BB Ural, DL Farber - Cell, 2021 - cell.com
Our immune system has evolved to protect us from pathogens and maintain homeostasis
through localization in diverse tissue sites throughout the body. Immune responses are …

[HTML][HTML] The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19

MA Almadhi, A Abdulrahman, SA Sharaf… - International journal of …, 2021 - Elsevier
Purpose The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths
worldwide since its outbreak. Public health responses have focused on identifying …