Immunology of aging: the birth of inflammaging

T Fulop, A Larbi, G Pawelec, A Khalil, AA Cohen… - Clinical reviews in …, 2021 - Springer
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention

A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …

Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing

L Mazini, L Rochette, B Admou, S Amal… - International journal of …, 2020 - mdpi.com
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within
subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal …

The beneficial roles of SIRT1 in neuroinflammation‐related diseases

F Jiao, Z Gong - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Frailty, aging, and periodontal disease: Basic biologic considerations

D Clark, E Kotronia, SE Ramsay - Periodontology 2000, 2021 - Wiley Online Library
Aging is associated with the development of disease. Periodontal disease is one of the
many diseases and conditions that increase in prevalence with age. In addition to the …