Last decade witnessed the outbreak of many life-threatening human pathogens including
Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS …

Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …

Psoriasis is a common heterogeneous inflammatory skin disease with a complex
pathophysiology and limited treatment options. Here we performed proteomic analyses of …

The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and
anti-inflammatory potential remains an ongoing challenge. Fcγ receptor-mediated effects of …

An increased understanding in the pathophysiology of chronic inflammatory diseases, such
as rheumatoid arthritis, reveals that the diseased tissue and the increased presence of …

Intravenous immunoglobulin (IVIG) is a therapeutic compound prepared from pools of
plasma obtained from several thousand healthy blood donors. For more than 20 years, IVIG …

The IgG molecule is the main component of IVIg. Commercial preparations of IVIg are
derived from a pool of donors and subsequently, IVIg products contain smaller amounts of …

Overexpression of antibody light chains in small plasma cell clones can lead to misfolding
and aggregation. On the other hand, the formation of amyloid fibrils from antibody light …

Prepared from the collective plasma of several thousand people, therapeutic intravenous
immunoglobulin (IVIg) consists mostly of human polyspecific IgG. In addition to its use in …

Objective To perform a systematic review and meta-analysis on the efficacy and safety of
intravenous (IVIg) and subcutaneous (SCIg) immunoglobulin (Ig) therapy in the treatment of …