[HTML][HTML] Therapeutic potential of loureirin A against SARS‐CoV‐2 infection

MR Khezri, D Moloodsouri, D Hodaei… - Phytotherapy …, 2022 - ncbi.nlm.nih.gov
To the Editor, The pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has led to an extraordinary threat to the global healthcare system …

[HTML][HTML] Discrete-state models identify pathway specific B cell states across diseases and infections at single-cell resolution

G Kassis, MG Palshikar, SP Hilchey, MS Zand… - Journal of theoretical …, 2024 - Elsevier
Oxygen (O 2) regulated pathways modulate B cell activation, migration and proliferation
during infection, vaccination, and other diseases. Modeling these pathways in health and …

Gene network analysis of the transcriptome impact of SARS-CoV-2 interacting microRNAs in COVID-19 disease

AI Moatar, AR Chis, C Marian, IO Sirbu - International journal of molecular …, 2022 - mdpi.com
According to the World Health Organization (WHO), as of June 2022, over 536 million
confirmed COVID-19 disease cases and over 6.3 million deaths had been globally reported …

Therapeutic Path to Triple Knockout: Investigating the Pan-inhibitory Mechanisms of AKT, CDK9, and TNKS2 by a Novel 2-phenylquinazolinone Derivative in Cancer …

XQ Peters, G Elamin, A Aljoundi… - Current …, 2024 - ingentaconnect.com
Background: Blocking the oncogenic Wnt//β-catenin pathway has of late been investigated
as a viable therapeutic approach in the treatment of cancer. This involves the multi-targeting …

Precision medicine for pandemics: stratification of COVID-19 molecular phenotypes defined by topological analysis of global blood gene expression.

R Penrice-Randal, F Strazzeri, B Ernst, B Van Eeckhout… - medRxiv, 2024 - medrxiv.org
Precision medicine offers a promising avenue for better therapeutic responses to pandemics
such as COVID-19. This study leverages independent patient cohorts in Florence and Liège …

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

CE Geyer, HJ Chen, AP Bye, XD Manz… - Life Science …, 2023 - life-science-alliance.org
Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play
a major role in disease severity in COVID-19 by triggering macrophage hyperactivation …

Repurposing drugs for viruses and cancer: A novel drug repositioning strategy for COVID-19

KH Wong, CM Lim, AJW Yip, IA Farouk… - Drug Repurposing for …, 2023 - Springer
The high infection capacity and rapid mutations in coronavirus disease 2019 (COVID-19)
has been no stranger to many. The etiological agent that contributed to this global health …

Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication in vivo

P de Antonellis, V Ferrucci, F Bibbo, F Asadzadeh… - medRxiv, 2022 - medrxiv.org
ATP2B1 is a known regulator of calcium (Ca2+) cellular export and homeostasis.
Diminished levels of extra-or intra-cellular Ca2+ content have been suggested to block …

[PDF][PDF] Molecular mechanisms revealed by network pharmacology of Xuebijing on the treatment of acute respiratory distress syndrome caused by novel coronavirus …

P Tao, L Jiming - European Review for Medical & …, 2022 - europeanreview.org
Molecular mechanisms revealed by network pharmacology of Xuebijing on the treatment of
acute respiratory distress syndrome cause Page 1 2651 Abstract. – OBJECTIVE: The study …

[PDF][PDF] The role and research progress of PI3K/AKT signaling pathway in non-traumatic osteonecrosis of the femoral head

FM Wang, YN Wang, ZY Wang, S Fu - Med Theor Hypothesis, 2023 - tmrjournals.cn
Non-traumatic osteonecrosis of the femoral head (NONFH) is one of the most common
orthopedic diseases, influenced by multiple signaling pathways and inflammatory factors …