Background Pathogen resistance and safety concerns limit oral antibiotic options for the
treatment of acute bacterial skin and skin structure infections (ABSSSI). We aimed to …

Objectives: To determine the therapeutic equivalence and safety of once daily (OD) versus
three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in …

Background Group A meningococci are the source of major epidemics of meningitis in
Africa. An affordable, highly immunogenic meningococcal A conjugate vaccine is needed …

The relationship between two independent binomial proportions is commonly estimated and
presented using the difference between proportions, the number needed to treat, the ratio of …

OBJECTIVE: To compare the safety and efficacy of the transobturator tape to tension-free
vaginal tape (TVT) in the treatment of stress urinary incontinence in patients with and without …

ContextWhen unfractionated heparin is used to treat acute venous thromboembolism, it is
usually administered by intravenous infusion with coagulation monitoring, which requires …

Ein fundiertes Referenzwerk zu den statistischen Instrumenten und Softwareprogrammen,
die für das Design und die Planung klinischer Studien erforderlich sind. Die erweiterte 4 …

Importance This is the first large-scale randomized clinical trial evaluating the effectiveness
and safety of overminus spectacle therapy for treatment of intermittent exotropia (IXT) …

The adequacy of sample size is important to clinical trials. In the planning phase of a trial,
however, the investigators are often quite uncertain about the sizes of parameters which are …

We aimed at demonstrating non-inferiority of bortezomib/cyclophosphamide/
dexamethasone (VCD) compared to bortezomib/doxorubicin/dexamethasone (PAd) …