[HTML][HTML] Epigenomic insights into common human disease pathology
CG Bell - Cellular and Molecular Life Sciences, 2024 - Springer
The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …
genome—enables the same genetic template to be activated or repressed in different …
Genetic regulation of m6A RNA methylation and its contribution in human complex diseases
K Chen, J Nan, X Xiong - Science China Life Sciences, 2024 - Springer
Abstract N 6-methyladenosine (m6A) has been established as the most prevalent chemical
modification in message RNA (mRNA), playing an essential role in determining the fate of …
modification in message RNA (mRNA), playing an essential role in determining the fate of …
[HTML][HTML] Fine-mapping causal tissues and genes at disease-associated loci
Heritable diseases often manifest in a highly tissue-specific manner, with different disease
loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine …
loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine …
[HTML][HTML] The transcription factor ZNF469 regulates collagen production in liver fibrosis
S Steinhauser, D Estoppey, DP Buehler, Y Xiong… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD)-characterized by excess accumulation of fat in the
liver-now affects one third of the world's population. As NAFLD progresses, extracellular …
liver-now affects one third of the world's population. As NAFLD progresses, extracellular …
Atlas of imprinted and allele-specific DNA methylation in the human body
J Rosenski, A Peretz, J Magenheim, N Loyfer… - bioRxiv, 2024 - biorxiv.org
Allele-specific DNA methylation, determined genetically or epigenetically, is involved in
gene regulation and underlies multiple pathologies. Yet, our knowledge of this phenomenon …
gene regulation and underlies multiple pathologies. Yet, our knowledge of this phenomenon …
Discriminative histone imputation using chromatin accessibility
W Wen, J Zhong, Z Zhang, L Jia, T Chu, N Wang… - bioRxiv, 2024 - biorxiv.org
Motivation: Histone modifications (HMs) play a crucial role in various biological processes,
including transcription, replication, and DNA repair, and they have a significant impact on …
including transcription, replication, and DNA repair, and they have a significant impact on …