Macrophage polarization and reprogramming in acute inflammation: a redox perspective

S Pérez, S Rius-Pérez - Antioxidants, 2022 - mdpi.com
Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Current gaps in sepsis immunology: new opportunities for translational research

I Rubio, MF Osuchowski, M Shankar-Hari… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

CD4 T cell responses and the sepsis-induced immunoparalysis state

MD Martin, VP Badovinac, TS Griffith - Frontiers in immunology, 2020 - frontiersin.org
Sepsis remains a major cause of death in the United States and worldwide, and costs
associated with treating septic patients place a large burden on the healthcare industry …

The trinity of cGAS, TLR9, and ALRs guardians of the cellular galaxy against host-derived self-DNA

V Kumar - Frontiers in Immunology, 2021 - frontiersin.org
The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Coronavirus disease 2019 (COVID‐19) update: From metabolic reprogramming to immunometabolism

M Rudiansyah, SA Jasim… - Journal of Medical …, 2022 - Wiley Online Library
The field of immunometabolism investigates and describes the effects of metabolic rewiring
in immune cells throughout activation and the fates of these cells. Recently, it has been …

Adipose tissue macrophages: Unique polarization and bioenergetics in obesity

HL Caslin, M Bhanot, WR Bolus… - Immunological …, 2020 - Wiley Online Library
Macrophages comprise a majority of the resident immune cells in adipose tissue (AT) and
regulate both tissue homeostasis in the lean state and metabolic dysregulation in obesity …

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

J Su, K Guo, M Huang, Y Liu, J Zhang, L Sun… - Frontiers in …, 2019 - frontiersin.org
Background: Fucoxanthin (FX), a xanthophyll pigment which occurs in marine brown algae
with remarkable biological properties, has been proven to be safe for consumption by …

Protective role of the novel cytokine Metrnl/interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 …

X Chen, X Chen, Y Yang, N Luo, J Yang, L Zhong… - Clinical …, 2023 - Elsevier
Background Metrnl play an immunocytokine-like role in several diseases, which is also
known as meteorin-like because it is homologous to the neurotrophic factor meteorin …

How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?

V Kumar - International reviews of immunology, 2021 - Taylor & Francis
SARS-CoV2 infection or COVID-19 has created panic around the world since its first origin
in December 2019 in Wuhan city, China. The COVID-19 pandemic has infected more than …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …