Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …

Abstract JASPAR (https://jaspar. elixir. no/) is a widely-used open-access database
presenting manually curated high-quality and non-redundant DNA-binding profiles for …

Abstract ChIP-Atlas (https://chip-atlas. org) is a web service providing both GUI-and API-
based data-mining tools to reveal the architecture of the transcription regulatory landscape …

Abstract ReMap (https://remap. univ-amu. fr) aims to provide manually curated, high-quality
catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Protective immunity against pathogens or cancer is mediated by the activation and clonal
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …

We present a major update of the HOCOMOCO collection that provides DNA binding
specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make …

Epigenetic dysregulation may influence disease progression. Here we explore whether
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …