Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

The current status of phage therapy and its advancement towards establishing standard antimicrobials for combating multi drug-resistant bacterial pathogens

Y Ali, I Inusa, G Sanghvi, VB Mandaliya… - Microbial Pathogenesis, 2023 - Elsevier
Phage therapy; a revived antimicrobial weapon, has great therapeutic advantages with the
main ones being its ability to eradicate multidrug-resistant pathogens as well as selective …

What's in a Name? An overview of the proliferating nomenclature in the field of phage lysins

R Vázquez, Y Briers - Cells, 2023 - mdpi.com
In the last few years, the volume of research produced on phage lysins has grown
spectacularly due to the interest in using them as alternative antimicrobials. As a result, a …

Natural killers: opportunities and challenges for the use of bacteriophages in microbial food safety from the one health perspective

M Lavilla, P Domingo-Calap, S Sevilla-Navarro… - Foods, 2023 - mdpi.com
Ingestion of food or water contaminated with pathogenic bacteria may cause serious
diseases. The One Health approach may help to ensure food safety by anticipating …

The use of bacteriophages in biotechnology and recent insights into proteomics

AG Abril, M Carrera, V Notario, Á Sánchez-Pérez… - Antibiotics, 2022 - mdpi.com
Phages have certain features, such as their ability to form protein–protein interactions, that
make them good candidates for use in a variety of beneficial applications, such as in human …

Experimental evolution of the TolC-receptor phage U136B functionally identifies a tail fiber protein involved in adsorption through strong parallel adaptation

AR Burmeister, E Tzintzun-Tapia, C Roush… - Applied and …, 2023 - Am Soc Microbiol
Bacteriophages have received recent attention for their therapeutic potential to treat
antibiotic-resistant bacterial infections. One particular idea in phage therapy is to use …

Recent advances in phage therapy for pharmaceutical applications

ES Saral-Acarca, E Evran, EK Tayyarcan… - Journal of Drug Delivery …, 2023 - Elsevier
Antibiotic resistance poses a significant challenge for the treatment of infections. The
development of a new formulation containing bacteriophages in the treatment of infections …

Identification of a virulent phage infecting species of Nitrosomonas

P Quirós, L Sala-Comorera, C Gómez-Gómez… - The ISME …, 2023 - academic.oup.com
In the first and limiting step of nitrification, ammonia (NH3) is oxidised to nitrite (NO2−) by the
action of some prokaryotes, including bacteria of the Nitrosomonas genus. A potential …

The Medicinal Phage—Regulatory Roadmap for Phage Therapy under EU Pharmaceutical Legislation

T Faltus - Viruses, 2024 - mdpi.com
Bacteriophage therapy is a promising approach to treating bacterial infections. Research
and development of bacteriophage therapy is intensifying due to the increase in antibiotic …

Phage therapy: breathing new tactics into lower respiratory tract infection treatments

A Vaezi, T Healy, G Ebrahimi… - European …, 2024 - err.ersjournals.com
Lower respiratory tract infections (LRTIs) present a significant global health burden,
exacerbated by the rise in antimicrobial resistance (AMR). The persistence and evolution of …