[HTML][HTML] Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

B Ying, TL Darling, P Desai, CY Liang, IP Dmitriev… - Nature …, 2024 - nature.com
A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used in India …

[HTML][HTML] Defending against SARS-CoV-2: The T cell perspective

P Almendro-Vázquez, R Laguna-Goya… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

[HTML][HTML] Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial

S Chalkias, F Eder, B Essink, S Khetan, B Nestorova… - Nature medicine, 2022 - nature.com
Updated immunization strategies are needed to address multiple severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants. Here we report interim results from an …

[HTML][HTML] Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …

[HTML][HTML] Immunologic effect of bivalent mRNA booster in patients undergoing hemodialysis

L Huth, L Schäfer, G Almanzar, G Lupoli… - … England Journal of …, 2023 - Mass Medical Soc
Bivalent SARS-CoV-2 Booster in Hemodialysis Patients In a group of patients undergoing
hemodialysis who had received four previous inoculations of SARS-CoV-2 vaccines, a fifth …

[HTML][HTML] Safety and immunogenicity of a tetravalent and bivalent SARS-CoV-2 protein booster vaccine in men

S Hannawi, L Saf Eldin, A Abuquta, A Alamadi… - Nature …, 2023 - nature.com
The safety and immunogenicity of a protein-based tetravalent vaccine SCTV01E that
contains spike protein ectodomain (S-ECD) of Alpha, Beta, Delta and Omicron BA. 1 are …

[HTML][HTML] Characterizing SARS-CoV-2 neutralization profiles after bivalent boosting using antigenic cartography

A Rössler, A Netzl, L Knabl, D Bante, SH Wilks… - Nature …, 2023 - nature.com
Since emergence of the initial SARS-CoV-2 BA. 1, BA. 2 and BA. 5 variants, Omicron has
diversified substantially. Antigenic characterization of these new variants is important to …

Broad-spectrum pan-genus and pan-family virus vaccines

CW Tan, SA Valkenburg, LLM Poon, LF Wang - Cell Host & Microbe, 2023 - cell.com
Although the development and clinical application of SARS-CoV-2 vaccines during the
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …

[HTML][HTML] Toward a pan-SARS-CoV-2 vaccine targeting conserved epitopes on spike and non-spike proteins for potent, broad and durable immune responses

CY Wang, WJ Peng, BS Kuo, YH Ho, MS Wang… - PLoS …, 2023 - journals.plos.org
Background The SARS-CoV-2 non-Spike (S) structural protein targets on nucleocapsid (N),
membrane (M) and envelope (E), critical in the host cell interferon response and memory T …

Safety and immunogenicity of multivalent SARS-CoV-2 protein vaccines: A randomized phase 3 trial

S Hannawi, L Yan, L Saifeldin, A Abuquta… - …, 2023 - thelancet.com
Background COVID-19 vaccines that offer broad-spectrum protection are needed. We aimed
to evaluate the safety and immunogenicity of multivalent vaccines, SCTV01E and SCTV01C …