Guidance for the timing of surgery following SARS‐CoV‐2 infection needed reassessment
given widespread vaccination, less virulent variants, contemporary evidence and a need to …

One of the most consequential unknowns of the COVID‐19 pandemic is the frequency at
which vaccine boosting provides sufficient protection from infection. We quantified the …

The emergence of Omicron variants coincided with declining vaccine-induced protection
against SARS-CoV-2. Two bivalent mRNA vaccines, mRNA-1273.222 (Moderna) and …

Combining optimized spike (S) protein-encoding mRNA vaccines to target multiple SARS-
CoV-2 variants could improve control of the COVID-19 pandemic. We compare monovalent …

ABSTRACT Background Protection from SARS-CoV-2 vaccines wanes over time and is
compounded by emerging variants including Omicron subvariants. This study evaluated …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
challenge the efficacy of approved vaccines, emphasizing the need for updated spike …

Effectiveness of the 50-μg mRNA-1273.214 bivalent vaccine against SARS-CoV-2 infection
was modest at 25% in a matched, retrospective, cohort study in Qatar comparing infection …

Background A rapidly growing body was observed of literature evaluating the vaccine
effectiveness (VE) against Omicron in test-negative design studies. Methods We …

Current COVID-19 vaccines are highly effective against symptomatic disease, but repeated
booster doses using vaccines based on the ancestral strain offer limited additional …

Currently approved COVID vaccines are designed using the spike antigen derived from the
ancestral strain, but health authorities are recommending changes to the vaccine strain to …