Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

A recent case report described an individual who was a homozygous carrier of the APOE3
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …

The complex molecular mechanism and pathophysiology of Alzheimer's disease (AD) limits
the development of effective therapeutics or prevention strategies. Artificial Intelligence (AI) …

Objective Debate surrounds the role of chronic pain as a risk factor for cognitive decline and
dementia. This study aimed at examining the association of chronic pain with biomarkers of …

The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …

Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …

Background Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …

We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments
from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid …

Background Alzheimer's disease (AD) is the most frequent cause of dementia. Recent
evidence suggests the involvement of peripheral immune cells in the disease, but the …

Objective Irisin, released by muscles during exercise, was recently identified as a
neuroprotective factor in mouse models of Alzheimer disease (AD). In a cohort of AD …