Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
[HTML][HTML] Genetic and stress-induced loss of NG2 glia triggers emergence of depressive-like behaviors through reduced secretion of FGF2
Summary NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active
pool of cells in the central nervous system (CNS). In addition to serving as progenitors of …
pool of cells in the central nervous system (CNS). In addition to serving as progenitors of …
[HTML][HTML] Glutamatergic and resting-state functional connectivity correlates of severity in major depression–the role of pregenual anterior cingulate cortex and anterior …
DI Horn, C Yu, J Steiner, J Buchmann… - Frontiers in systems …, 2010 - frontiersin.org
Glutamatergic mechanisms and resting-state functional connectivity alterations have been
recently described as factors contributing to major depressive disorder (MDD). Furthermore …
recently described as factors contributing to major depressive disorder (MDD). Furthermore …
Cocaine self-administration and extinction leads to reduced glial fibrillary acidic protein expression and morphometric features of astrocytes in the nucleus accumbens …
Background As a more detailed picture of nervous system function emerges, diversity of
astrocyte function becomes more widely appreciated. While it has been shown that cocaine …
astrocyte function becomes more widely appreciated. While it has been shown that cocaine …
Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications
Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression
Background Evidence continues to build suggesting that the GABAergic neurotransmitter
system is altered in brains of patients with major depressive disorder. However, there is little …
system is altered in brains of patients with major depressive disorder. However, there is little …
Cell atrophy and loss in depression: reversal by antidepressant treatment
Depression is associated with structural alterations in limbic brain regions that control
emotion and mood. Studies of chronic stress in animal models and postmortem tissue from …
emotion and mood. Studies of chronic stress in animal models and postmortem tissue from …
Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder
BACKGROUND: Significant alterations in γ-aminobutyric acid (GABA) and glutamate levels
have been previously reported in symptomatic and remitted major depressive disorder …
have been previously reported in symptomatic and remitted major depressive disorder …
The 'resting-state hypothesis' of major depressive disorder—A translational subcortical–cortical framework for a system disorder
G Northoff, C Wiebking, T Feinberg… - … & Biobehavioral Reviews, 2011 - Elsevier
Major depressive disorder (MDD) has traditionally been characterized by various
psychological symptoms, involvement of diverse functional systems (eg, somatic, affect …
psychological symptoms, involvement of diverse functional systems (eg, somatic, affect …