Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Z Pang, G Zhou, J Ewald, L Chang, O Hacariz… - Nature protocols, 2022 - nature.com
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

E Mishima, J Ito, Z Wu, T Nakamura, A Wahida, S Doll… - Nature, 2022 - nature.com
Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation,
has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant …

[HTML][HTML] Phase separation of FSP1 promotes ferroptosis

T Nakamura, C Hipp, A Santos Dias Mourão… - Nature, 2023 - nature.com
Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour
entities including therapy-refractory and dedifferentiating cancers,–. Recently, ferroptosis …

HMDB 5.0: the human metabolome database for 2022

DS Wishart, AC Guo, E Oler, F Wang… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Human Metabolome Database or HMDB (https://hmdb. ca) has been providing
comprehensive reference information about human metabolites and their associated …

Lymph protects metastasizing melanoma cells from ferroptosis

JM Ubellacker, A Tasdogan, V Ramesh, B Shen… - Nature, 2020 - nature.com
Cancer cells, including melanoma cells, often metastasize regionally through the lymphatic
system before metastasizing systemically through the blood,,–; however, the reason for this …

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

G Wang, J Li, L Bojmar, H Chen, Z Li, GC Tobias, M Hu… - Nature, 2023 - nature.com
Cancer alters the function of multiple organs beyond those targeted by metastasis,. Here we
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …

Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism

Z Zhang, X Mu, Q Cao, Y Shi, X Hu, H Zheng - Nature Communications, 2022 - nature.com
Honeybees are highly social insects with a rich behavioral repertoire and are a versatile
model for neurobiological research. Their gut microbiota comprises a limited number of host …

[HTML][HTML] COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

T Thomas, D Stefanoni, JA Reisz, T Nemkov… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …

Evidence of structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients

T Thomas, D Stefanoni, M Dzieciatkowska… - Journal of proteome …, 2020 - ACS Publications
The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is
primarily characterized by shortness of breath, persistent dry cough, and fever. Because they …