Colorectal cancer (CRC) represents 10% of all cancer types, making it the third leading
cause of cancer-related deaths globally. Metastasis is the primary factor causing mortality in …

Ferroptosis is a type of regulated cell death characterized by iron accumulation and
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …

Chemoproteomics has made significant progress in investigating small-molecule-protein
interactions. However, the proteome-wide profiling of cysteine ligandability remains …

Abstract Background Approximately 20–50% of patients presenting with localized colorectal
cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is …

Type I interferons (IFNs) are produced by almost all cell types and play a vital role in host
defense against viral infection. Infection with an RNA virus activates receptors such as RIG-I …

High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and
various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly …

Large amounts of adenosine triphosphate (ATP), a natural P2X7 receptor activator, are
released during colorectal carcinogenesis. P2X7 receptor activation regulates the activity of …

L‐Sorbosone dehydrogenase (SNDH) is a key enzyme involved in the biosynthesis of 2‐
keto‐L‐gulonic acid, which is a direct precursor for the industrial scale production of vitamin …

Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include
surgical resection and radiotherapy. However, local recurrence, distal metastasis, and …

Background Colorectal cancer (CRC) is a common malignancy that can significantly
diminish patients' quality of life. Astragalus mongholicus Bunge-Curcuma aromatica …