A systematic review of polycyclic aromatic hydrocarbon derivatives: occurrences, levels, biotransformation, exposure biomarkers, and toxicity

B Peng, Q Dong, F Li, T Wang, X Qiu… - Environmental Science & …, 2023 - ACS Publications
Polycyclic aromatic hydrocarbon (PAH) derivatives constitute a significant class of emerging
contaminants that have been ubiquitously detected in diverse environmental matrixes, with …

Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

P Kovacic, R Somanathan - Journal of Applied Toxicology, 2014 - Wiley Online Library
Vehicle pollution is an increasing problem in the industrial world. Aromatic nitro compounds
comprise a significant portion of the threat. In this review, the class includes nitro derivatives …

Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion

KM Ashry, YS El-Sayed, RM Khamiss… - Food and Chemical …, 2010 - Elsevier
The possible role of Commiphora molmol emulsion (CME) in protecting against lead (PbAc)-
induced hepatotoxicity, oxidative stress and immunotoxicity in rabbits was assessed. Six …

Clinical physiology and mechanism of dizocilpine (MK‐801): Electron transfer, radicals, redox metabolites and bioactivity

P Kovacic, R Somanathan - Oxidative medicine and cellular …, 2010 - Wiley Online Library
Dizocilpine (MK‐801), an extensively investigated drug possessing secondary amine and
benzenoid functions, displays a wide array of biological properties, including anticonvulsant …

Electromagnetic fields: mechanism, cell signaling, other bioprocesses, toxicity, radicals, antioxidants and beneficial effects

P Kovacic, R Somanathan - Journal of Receptors and Signal …, 2010 - Taylor & Francis
Electromagnetic fields (EMFs) played a role in the initiation of living systems, as well as
subsequent evolution. The more recent literature on electrochemistry is documented, as well …

Multifaceted approach to resveratrol bioactivity: focus on antioxidant action, cell signaling and safety

P Kovacic, R Somanathan - Oxidative medicine and cellular …, 2010 - Wiley Online Library
Resveratrol (RVT) is a naturally occurring trihydroxy stilbene that displays a wide spectrum
of physiological activity. Its ability to behave therapeutically as a component of red wine has …

How safe is bisphenol A? Fundamentals of toxicity: metabolism, electron transfer and oxidative stress

P Kovacic - Medical hypotheses, 2010 - Elsevier
The FDA recently announced concern about the safety of bisphenol A (BPA) and the need
for more research. In the current controversy, scant attention is being paid to toxicity at the …

[HTML][HTML] Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin

P Ma, B Yan, Q Zeng, X Liu, Y Wu, M Jiao, C Liu… - Food and Chemical …, 2014 - Elsevier
Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and
is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined …

[HTML][HTML] The HL-60 human promyelocytic cell line constitutes an effective in vitro model for evaluating toxicity, oxidative stress and necrosis/apoptosis after exposure to …

RAS Benavides, JM Leiro-Vidal… - Science of the Total …, 2023 - Elsevier
The cellular and molecular mechanisms by which atmospheric pollution from particulate
matter and/or electromagnetic fields (EMFs) may prove harmful to human health have not …

Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications

P Kovacic - Medical hypotheses, 2011 - Elsevier
During a century, hydroxyurea has received much attention in relation to its physiological
properties. This review mainly deals with the metabolism, mechanism, cell signaling …