MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …

RNA plays a central role in the expression of all genes. Because any sequence within RNA
can be recognized by complementary base pairing, synthetic oligonucleotides and …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …