Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …