Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization
AM Astudillo, MA Balboa, J Balsinde - … (BBA)-Molecular and Cell Biology of …, 2019 - Elsevier
Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA …
are key mediators of a wide variety of physiological and pathophysiological states. AA …
Dynamics of arachidonic acid mobilization by inflammatory cells
AM Astudillo, D Balgoma, MA Balboa… - Biochimica et Biophysica …, 2012 - Elsevier
The development of mass spectrometry-based techniques is opening new insights into the
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …
Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells
Recent studies have highlighted the role of palmitoleic acid [16: 1n-7 (cis-9-hexadecenoic
acid)] as a lipid hormone that coordinates cross-talk between liver and adipose tissue and …
acid)] as a lipid hormone that coordinates cross-talk between liver and adipose tissue and …
Phospholipase A2 regulation of lipid droplet formation
The classical regard of lipid droplets as mere static energy-storage organelles has evolved
dramatically. Nowadays these organelles are known to participate in key processes of cell …
dramatically. Nowadays these organelles are known to participate in key processes of cell …
Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes
Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in the
rapid induction of lipid droplet (LD) formation by these cells. This effect appears specific for …
rapid induction of lipid droplet (LD) formation by these cells. This effect appears specific for …
Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens
Macrophages, as professional phagocytes of the immune system, possess the ability to
detect and clear invading pathogens and apoptotic cells through phagocytosis …
detect and clear invading pathogens and apoptotic cells through phagocytosis …
Cellular Plasmalogen Content Does Not Influence Arachidonic Acid Levels or Distribution in Macrophages: A Role for Cytosolic Phospholipase A2γ in Phospholipid …
P Lebrero, AM Astudillo, JM Rubio… - Cells, 2019 - mdpi.com
Availability of free arachidonic acid (AA) constitutes a rate limiting factor for cellular
eicosanoid synthesis. AA distributes differentially across membrane phospholipids, which is …
eicosanoid synthesis. AA distributes differentially across membrane phospholipids, which is …
Group V secreted phospholipase A2 is upregulated by IL-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids
Studies on the heterogeneity and plasticity of macrophage populations led to the
identification of two major polarization states: classically activated macrophages or M1 …
identification of two major polarization states: classically activated macrophages or M1 …