Determinants of genetic diversity

H Ellegren, N Galtier - Nature Reviews Genetics, 2016 - nature.com
Genetic polymorphism varies among species and within genomes, and has important
implications for the evolution and conservation of species. The determinants of this variation …

[HTML][HTML] Transposable elements in Drosophila

V Mérel, M Boulesteix, M Fablet, C Vieira - Mobile DNA, 2020 - Springer
Drosophila has been studied as a biological model for many years and many discoveries in
biology rely on this species. Research on transposable elements (TEs) is not an exception …

Robust and scalable inference of population history from hundreds of unphased whole genomes

J Terhorst, JA Kamm, YS Song - Nature genetics, 2017 - nature.com
It has recently been demonstrated that inference methods based on genealogical processes
with recombination can uncover past population history in unprecedented detail. However …

Genetics on the Fly: A Primer on the Drosophila Model System

KG Hales, CA Korey, AM Larracuente, DM Roberts - Genetics, 2015 - academic.oup.com
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

[HTML][HTML] Deep learning for population genetic inference

S Sheehan, YS Song - PLoS computational biology, 2016 - journals.plos.org
Given genomic variation data from multiple individuals, computing the likelihood of complex
population genetic models is often infeasible. To circumvent this problem, we introduce a …

[HTML][HTML] The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster

CL Webster, FM Waldron, S Robertson, D Crowson… - PLoS …, 2015 - journals.plos.org
Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …

Toward an evolutionarily appropriate null model: jointly inferring demography and purifying selection

P Johri, B Charlesworth, JD Jensen - Genetics, 2020 - academic.oup.com
The relative evolutionary roles of adaptive and non-adaptive processes remain a central
question in population genetics. Resolution of this debate has been difficult as an …

[PDF][PDF] Predicting the landscape of recombination using deep learning

JR Adrion, JG Galloway, AD Kern - Molecular biology and …, 2020 - academic.oup.com
Accurately inferring the genome-wide landscape of recombination rates in natural
populations is a central aim in genomics, as patterns of linkage influence everything from …

[HTML][HTML] Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits

M Chakraborty, JJ Emerson, SJ Macdonald… - Nature …, 2019 - nature.com
It has been hypothesized that individually-rare hidden structural variants (SVs) could
account for a significant fraction of variation in complex traits. Here we identified more than …

Phylogeny of the Genus Drosophila

PM O'Grady, R DeSalle - Genetics, 2018 - academic.oup.com
Understanding phylogenetic relationships among taxa is key to designing and implementing
comparative analyses. The genus Drosophila, which contains over 1600 species, is one of …