Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome

N Kozono, A Okamura, S Honda, M Matsumoto… - Scientific reports, 2020 - nature.com
Fragile X syndrome (FXS) is characteristically displayed intellectual disability, hyperactivity,
anxiety, and abnormal sensory processing. Electroencephalography (EEG) abnormalities …

Altered gut microbiota in a fragile X syndrome mouse model

F Altimiras, JA Garcia, I Palacios-García… - Frontiers in …, 2021 - frontiersin.org
The human gut microbiome is the ecosystem of microorganisms that live in the human
digestive system. Several studies have related gut microbiome variants to metabolic …

Visual experience-dependent oscillations and underlying circuit connectivity changes are impaired in Fmr1 KO mice

ST Kissinger, Q Wu, CJ Quinn, AK Anderson, A Pak… - Cell reports, 2020 - cell.com
Fragile X syndrome (FX), the most common inherited form of autism and intellectual
disability, is a condition associated with visual perceptual learning deficits. We recently …

Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome

K Juczewski, H von Richthofen, C Bagni, T Celikel… - Neurobiology of …, 2016 - Elsevier
Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by the
absence or reduction of the fragile X mental retardation protein (FMRP) encoded by the …

Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder

K Anshu, AK Nair, UD Kumaresan, BM Kutty… - Autism …, 2017 - Wiley Online Library
Attention is foundational to efficient perception and optimal goal driven behavior. Intact
attentional processing is crucial for the development of social and communication skills …

[PDF][PDF] Disrupted cortical state regulation in a rat model of fragile X syndrome

J Berzhanskaya, MA Phillips, A Gorin, C Lai… - Cerebral …, 2016 - academic.oup.com
Children with Fragile X syndrome (FXS) have deficits of attention and arousal. To begin to
identify the neural causes of these deficits, we examined juvenile rats lacking the Fragile X …

Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome

HGS Martin, O Lassalle, JT Brown… - Cerebral cortex, 2016 - academic.oup.com
The most common inherited monogenetic cause of intellectual disability is Fragile X
syndrome (FXS). The clinical symptoms of FXS evolve with age during adulthood; however …

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice

S Logan, D Owen, S Chen, WJ Chen, Z Ungvari… - Geroscience, 2018 - Springer
Cognitive function declines substantially with age in both humans and animal models. In
humans, this decline is associated with decreases in independence and quality of life …

Anxiety, hyperactivity and stereotypy in a zebrafish model of fragile X syndrome and autism spectrum disorder

L Kim, L He, H Maaswinkel, L Zhu, H Sirotkin… - Progress in Neuro …, 2014 - Elsevier
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is
caused by a loss of function of the fragile X mental retardation (fmr1) gene. Animal fmr1 …

Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

TL Schaefer, MH Davenport, LM Grainger… - Journal of …, 2017 - Springer
Abstract Background Fragile X Syndrome (FXS) occurs as a result of a silenced fragile X
mental retardation 1 gene (FMR1) and subsequent loss of fragile X mental retardation …