[HTML][HTML] Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

[HTML][HTML] Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review

WA Awuah, H Huang, J Kalmanovich, A Mehta… - Medicine, 2023 - journals.lww.com
The circadian rhythm (CR) is a fundamental biological process regulated by the Earth's
rotation and solar cycles. It plays a critical role in various bodily functions, and its …

Spiroindole-containing compounds bearing phosphonate group of potential Mpro-SARS-CoV-2 inhibitory properties

MS Bekheit, SS Panda, BM Kariuki… - European Journal of …, 2023 - Elsevier
Abstract Microwave-assisted reaction of 3, 5-bis ((E)-ylidene)-1-phosphonate-4-piperidones
3a‒g with azomethine ylide (produced through interaction of isatins 4 and sarcosine 5) …

[HTML][HTML] Hippo-YAP signaling and SARS-CoV-2 infection: a new mechanistic pathway

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - Cell Stress and …, 2023 - Springer
Coronavirus disease 2019 (COVID-19) is the current pandemic caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2)(Babalghith et al. 2022). SARS-CoV …

[HTML][HTML] Strictinin, a major ingredient in Yunnan kucha tea possessing inhibitory activity on the infection of mouse hepatitis virus to mouse L cells

EC Tu, WL Hsu, JTC Tzen - Molecules, 2023 - mdpi.com
Theacrine and strictinin of Yunnan Kucha tea prepared from a mutant variety of wild Pu'er
tea plants were two major ingredients responsible for the anti-influenza activity. As the …

[HTML][HTML] Melatonin and viral infections: a review focusing on therapeutic effects and SARS-CoV-2

L Chacín-Bonilla, E Bonilla - Melatonin Research, 2024 - melatonin-research.net
Viral infections can cause serious diseases which lead to significant morbidity and mortality
of patients. In most cases, effective therapeutic approaches are lacking. Melatonin (MEL), a …

[HTML][HTML] Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …

[HTML][HTML] Melatonin Modulates Lipid Metabolism and Reduces Cardiovascular Risk in Apolipoprotein E-Deficient Mice Fed a Western Diet

G Santos-Sánchez, AI Álvarez-López, E Ponce-España… - Nutraceuticals, 2024 - mdpi.com
Melatonin (MLT), a natural compound found in the animal and vegetable kingdom,
participates in several physiological processes. MLT exerts antioxidant and anti …

Melatonin and Covid-19: An opened Pandora's box and the hope for the time being

L Chacín-Bonilla, E Bonilla - Melatonin Research, 2023 - melatonin-research.net
The SARS-CoV-2 pandemic is a global health concern still ongoing. No single therapeutic
intervention with high efficacy exists and virus mutations continue to improve immune …

The interplay between circadian clock and viral infections: A molecular perspective

E Kalita, M Panda, VK Prajapati - Advances in Protein Chemistry and …, 2023 - Elsevier
The circadian clock influences almost every aspect of mammalian behavioral, physiological
and metabolic processes. Being a hierarchical network, the circadian clock is driven by the …