TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …

Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an
irreversible decline of lung function.“Bronchiolization”, characterized by ectopic appearance …

Activation of the Ca2+ activated Cl− channel TMEM16A is proposed as a treatment in
inflammatory airway disease. It is assumed that activation of TMEM16A will induce …

Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in
asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive …

In cells of the lung surface, cigarette smoke (CS) induces inflammatory and epithelial-
mesenchymal transition (EMT), effects that are related to pulmonary dysfunction and Chronic …

Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble
mucins to the tear film that bathes the ocular surface. CGC numbers and functions are …

The airway epithelium is a critical component of the respiratory system, serving as a barrier
against inhaled pathogens and toxins. It is composed of various cell types, each with specific …

Ceramides are an emerging class of anti-inflammatory lipids, and nanoscale ceramide-
delivery systems are potential therapeutic strategies for inflammatory diseases. This study …

Airway mucus hypersecretion contributes to the morbidity and mortality in patients with
chronic inflammatory lung diseases. Reducing mucus production is crucial for improving …

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation.
This generic term encompasses emphysema and chronic bronchitis, two common …