Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for
which successful therapeutic options are still being investigated. Challenges facing current …

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …

CRISPR-Cas is a powerful genome editing technology and has a great potential for in vivo
gene therapy. Successful translational application of CRISPR-Cas to biomedicine still faces …

Human immunodeficiency virus (HIV) infection can be controlled by anti-retroviral therapy.
Suppressing viral replication relies on life-long medication, but anti-retroviral therapy is not …

Although tremendous efforts have been made to prevent and treat HIV-1 infection, HIV-
1/AIDS remains a major threat to global human health. The combination antiretroviral …

Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at
preventing viral replication but fail to eliminate the virus. Although transplantation of …

The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year,
the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 …

Although combination antiretroviral therapy (ART) has reduced mortality and improved
lifespan for people living with HIV, it does not provide a cure. Patients must be on ART for …

Abstract The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome
(AIDS) continues to be a major global public health issue, having claimed almost 33 million …