Recent advances and evolving concepts in Still's disease

P Ruscitti, L Cantarini, PA Nigrovic… - Nature Reviews …, 2024 - nature.com
Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …

Multisystem inflammatory syndrome in adults: Characteristics, treatment, and outcomes

CC Lai, CK Hsu, SC Hsueh, MY Yen… - Journal of Medical …, 2023 - Wiley Online Library
Following the rapidly increasing number of multisystem inflammatory syndromes in children
(MIS‐C), a similar clinical scenario has been observed in adult patients. Although its …

Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry

P Ruscitti, F Masedu, A Vitale, I Di Cola, V Caggiano… - RMD open, 2023 - rmdopen.bmj.com
Background Different patient clusters were preliminarily suggested to dissect the clinical
heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters …

The clinical heterogeneity of adult onset Still's disease may underlie different pathogenic mechanisms. Implications for a personalised therapeutic management of …

P Ruscitti, O Berardicurti, R Giacomelli… - Seminars in Immunology, 2021 - Elsevier
Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown aetiology
usually affecting young adults and manifesting with a clinical triad of spiking fever, arthritis …

Transcriptomic profiling and longitudinal study reveal the relationship of anti-MDA5 titer and type I IFN signature in MDA5+ dermatomyositis

Y Wang, H Jia, W Li, H Liu, M Tu, J Li, J Cheng… - Frontiers in …, 2023 - frontiersin.org
Objective This study aimed to investigate the relationship between anti-MDA5 titer and type I
IFN signature in patients with MDA5+ DM. Methods We explored the transcriptome profiling …

AOSD endotypes based on immune cell profiles: patient stratification with hierarchical clustering analysis

R Guo, X Liu, Y Li, X Meng, R Li, X Chen, L Lu - Rheumatology, 2023 - academic.oup.com
Objectives This study aimed to analyse the immune cell profiles of adult-onset Still's disease
(AOSD) and to stratify disease-associated endotypes. Methods We included 95 cases of …

Perspectives on the use of non-biological pharmacotherapy for adult-onset Still's disease

I Di Cola, P Cipriani, P Ruscitti - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The treatment of the patients with adult-onset Still's disease (AOSD) remains
largely empirical and it is based on the administration of immunosuppressive drugs. In this …

The latest advances in the use of biological DMARDs to treat Still's disease

I Di Cola, P Ruscitti - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
Introduction Currently, the therapeutic management of Still's disease, a multisystemic
inflammatory rare disorder, is directed to target the inflammatory symptoms and signs of …

[HTML][HTML] Ferritin and myalgic encephalomyelitis/chronic fatigue syndrome in post COVID-19, an unexpected facet of the hyperferritinemic syndrome?

P Ruscitti, F Ursini, Y Shoenfeld - Journal of Psychosomatic …, 2023 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19) has provoked a catastrophic medical emergency
worldwide [1]. In the course of time from the beginning of this pandemic, subacute and long …

Liver Involvement is Associated with Higher Risk of Rapidly Progressive Interstitial Lung Disease and Mortality in Anti-Melanoma Differentiation-Associated Gene 5 …

X Yang, X Cui, X Yang, B Ren, X Cheng… - Journal of …, 2024 - Taylor & Francis
Purpose This study aimed to assess liver involvement and investigate its correlation with
rapidly progressive interstitial lung disease (RP-ILD) and mortality in anti-melanoma …