Cytotoxicity and autophagy induced by ivermectin via AMPK/mTOR signaling pathway in RAW264. 7 cells

X Wang, J Wang, P Zhang, C Zhang, W Wang, M Wu… - Molecules, 2023 - mdpi.com
The widespread and excessive use of ivermectin (IVM) will not only cause serious
environmental pollution, but will also affect metabolism of humans and other mammals that …

Ivermectin ameliorates bleomycin-induced lung fibrosis in male rats by inhibiting the inflammation and oxidative stress

F Habibi Razi, R Mohammad Jafari… - …, 2024 - Taylor & Francis
Background Idiopathic pulmonary fibrosis (IPF) is a pulmonary fibrotic disease characterized
by a poor prognosis, which its pathogenesis involves the accumulation of abnormal fibrous …

[HTML][HTML] A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases

SW Mohammed, NA El-Megrab, AA Hasan… - European Journal of …, 2024 - Elsevier
In recent years, ivermectin (IVM), an antiparasitic drug of low water solubility and poor oral
bioavailability, has shown a profound effect on inflammatory mediators involved in diseases …

Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65

X Gao, Y Xuan, Z Zhou, C Chen, DW Wang… - International …, 2024 - Elsevier
Background Myocarditis is an important clinical issue which lacks specific treatment by now.
Ivermectin (IVM) is an inhibitor of importin α/β-mediated nuclear translocation. This study …

Ivermectin affects neutrophil-induced inflammation through inhibition of hydroxylysine but stimulation of cathepsin G and phenylalanine secretion

SI Galkina, EA Golenkina, MV Serebryakova… - Biomedicines, 2022 - mdpi.com
The invasion and integrin-dependent adhesion of neutrophils to lung tissues and their
secretion lead to the development of pneumonia in various pulmonary pathologies …

Detection of Ivermectin Toxicity Using Some Biochemical and Immunological Assays in Mice

BK Al-Baggou - Egyptian Journal of Veterinary Sciences, 2023 - journals.ekb.eg
our study aims to detect acute and subacute toxicity caused by ivermectin by using some
biochemical and immunological assays in mice. Non-lethal toxic doses of ivermectin (30 and …