Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …

The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs)
and progressive podocyte depletion. While mammalian target of rapamycin–mediated …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

Podocyte injury is central to many forms of kidney disease, but transcriptional signatures
reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo …

Podocytes are highly specialized epithelial cells that surround the capillaries of the
glomeruli in the kidney. Together with the glomerular endothelial cells, these postmitotic …

Podocytes are differentiated post-mitotic cells that cannot replace themselves after injury.
Glomerular parietal epithelial cells are proposed to be podocyte progenitors. To test whether …

An incomplete understanding of the biology of the human kidney, including the relative
abundances of and interactions between intrinsic and immune cells, has long constrained …

Summary Prostaglandin E 2 (PGE 2) has recently been recognized to play a role in immune
regulation and tissue regeneration. However, the short half-life of PGE 2 limits its clinical …

Healthy aging is typified by a progressive and absolute loss of podocytes over the lifespan of
animals and humans. To test the hypothesis that a subset of glomerular parietal epithelial …