Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

M Thoms, R Buschauer, M Ameismeier, L Koepke… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of …

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

J Loo, DA Spittle, M Newnham - Thorax, 2021 - thorax.bmj.com
Thrombotic events that frequently occur in COVID-19 are predominantly venous
thromboemboli (VTE) and are associated with increasing disease severity and worse clinical …

Antibody response to SARS-CoV-2 infection in humans: A systematic review

N Post, D Eddy, C Huntley, MCI Van Schalkwyk… - PloS one, 2020 - journals.plos.org
Background Progress in characterising the humoral immune response to Severe Acute
Respiratory Syndrome 2 (SARS-CoV-2) has been rapid but areas of uncertainty persist …

[HTML][HTML] An immune-based biomarker signature is associated with mortality in COVID-19 patients

MS Abers, OM Delmonte, EE Ricotta, J Fintzi, DL Fink… - JCI insight, 2021 - ncbi.nlm.nih.gov
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19) …

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …

Analysis of SARS-CoV-2 vertical transmission during pregnancy

C Fenizia, M Biasin, I Cetin, P Vergani, D Mileto… - Nature …, 2020 - nature.com
The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the
viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal …

[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

[HTML][HTML] Association of inflammatory markers with the severity of COVID-19: A meta-analysis

F Zeng, Y Huang, Y Guo, M Yin, X Chen, L Xiao… - International Journal of …, 2020 - Elsevier
Objectives Studies reported associations of inflammatory markers with the severity of COVID-
19, but conclusions were inconsistent. We aimed to provide an overview of the association …

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …