Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Age-related pathological alterations of the vasculature have a critical role in morbidity and
mortality of older adults. In epidemiological studies, age is the single most important …

Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

Cognitive impairment and dementia are major medical, social, and economic public health
issues worldwide with significant implications for life quality in older adults. The leading …