Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

Phagocytosis is a dynamic process that requires an intricate interplay between phagocytic
receptors, membrane lipids, and numerous signalling proteins and their effectors, to …

During MHC‐I‐restricted antigen processing, peptides generated by cytosolic proteasomes
are translocated by the transporter associated with antigen processing (TAP) into the …

ABC transporters fulfill diverse physiological functions in different cellular localizations
ranging from the plasma membrane to intracellular membranous compartments. Several …

Cross-presentation (XPT) is an adaptation of the cellular process in which dendritic cells
(DCs) present exogenous antigens on major histocompatibility complex (MHC) class I …

Highlights•TAP-independent peptides derive not only from membrane or secreted proteins,
but also from cytosolic ones.•The structure of the luminal part of the PLC has been …

The major histocompatibility complexes of vertebrates play a key role in the immune
response. Antigen-presenting cells are loaded on MHC I molecules, which mainly present …

Cellular life depends on transport and communication across membranes, which is
emphasized by the fact that membrane proteins are prime drug targets. The cell-like …

The human lysosomal polypeptide ABC transporter TAPL (ABC subfamily B member 9,
ABCB9) transports 6–59-amino-acid-long polypeptides from the cytosol into lysosomes. The …

Introduction Lactococcus lactis (LL) is safe and can be used as vehicle. In this study, the
immunoregulatory effect of LL on dendritic cell (DC) activation and mechanism were …