Forum on immune digital twins: a meeting report
Medical digital twins are computational models of human biology relevant to a given medical
condition, which are tailored to an individual patient, thereby predicting the course of …
condition, which are tailored to an individual patient, thereby predicting the course of …
Within‐host dynamics of SARS‐CoV‐2 infection: a systematic review and meta‐analysis
Z Du, S Wang, Y Bai, C Gao, EHY Lau… - Transboundary and …, 2022 - Wiley Online Library
Within‐host model specified by viral dynamic parameters is a mainstream tool to understand
SARS‐CoV‐2 replication cycle in infected patients. The parameter uncertainty further affects …
SARS‐CoV‐2 replication cycle in infected patients. The parameter uncertainty further affects …
[HTML][HTML] Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses
The viral kinetics of documented SARS-CoV-2 infections exhibit a high degree of
interindividual variability. We identified 6 distinct viral shedding patterns, which differed …
interindividual variability. We identified 6 distinct viral shedding patterns, which differed …
Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between …
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without
symptoms to acute respiratory distress and death. Empirical evidence points to the …
symptoms to acute respiratory distress and death. Empirical evidence points to the …
[HTML][HTML] Public health impact of Paxlovid as treatment for COVID-19, United States
We evaluated the population-level benefits of expanding treatment with the antiviral drug
Paxlovid (nirmatrelvir/ritonavir) in the United States for SARS-CoV-2 Omicron variant …
Paxlovid (nirmatrelvir/ritonavir) in the United States for SARS-CoV-2 Omicron variant …
Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy
AL Jenner, M Smalley, D Goldman, WF Goins… - Iscience, 2022 - cell.com
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …
Modeling within-host and aerosol dynamics of SARS-CoV-2: The relationship with infectiousness
N Heitzman-Breen, SM Ciupe - PLoS computational biology, 2022 - journals.plos.org
The relationship between transmission of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the amount of virus present in the proximity of a susceptible host is not …
(SARS-CoV-2) and the amount of virus present in the proximity of a susceptible host is not …
A simple model of COVID-19 explains disease severity and the effect of treatments
Considerable effort has been made to better understand why some people suffer from
severe COVID-19 while others remain asymptomatic. This has led to important clinical …
severe COVID-19 while others remain asymptomatic. This has led to important clinical …
Predicting the kinetic coordination of immune response dynamics in SARS-CoV-2 infection: implications for disease pathogenesis
D Grebennikov, A Karsonova, M Loguinova, V Casella… - Mathematics, 2022 - mdpi.com
A calibrated mathematical model of antiviral immune response to SARS-CoV-2 infection is
developed. The model considers the innate and antigen-specific responses to SARS-CoV-2 …
developed. The model considers the innate and antigen-specific responses to SARS-CoV-2 …
Identifiability of parameters in mathematical models of SARS-CoV-2 infections in humans
Determining accurate estimates for the characteristics of the severe acute respiratory
syndrome coronavirus 2 in the upper and lower respiratory tracts, by fitting mathematical …
syndrome coronavirus 2 in the upper and lower respiratory tracts, by fitting mathematical …