The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

The most severe forms of COVID-19 share many features with bacterial sepsis and have
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …

A recent meta-analysis 1 indicated that the majority of severely ill COVID-19 patients (78%)
met the Sepsis 3.0 criteria for sepsis/septic shock with acute respiratory distress syndrome …

Coronavirus disease 2019 is a respiratory infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence on the pathogenesis of SARS …

Introduction The European Medicines Agency (EMA) and the United States Food and Drug
Administration (FDA) announced conditions for using recombinant human interleukin-1 …

Severe manifestations of COVID-19 consist of acute respiratory distress syndrome due to an
initially local reaction leading to a systemic inflammatory response that results in hypoxia …

Immunothrombosis, an excessive inflammatory response with simultaneous overactivation
of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is …

An improved innate immunity will respond quickly to pathogens and initiate efficient adaptive
immune responses. However, up to now, there have been limited clinical ways for effective …

There is growing appreciation that skeletal muscle is a fully functional component of the
body's innate immune system with the potential to actively participate in the host response to …

Purpose To evaluate the efficacy of the novel oXiris® membrane in critically ill adult patients.
Methods We systematically searched MEDLINE, EMBASE, and CENTRAL from inception to …