BACKGROUND Multiple clinical trials failed to demonstrate the efficacy of hydrocortisone,
ascorbic acid, and thiamine (HAT) in sepsis. These trials were dominated by patients with …

There is growing appreciation that skeletal muscle is a fully functional component of the
body's innate immune system with the potential to actively participate in the host response to …

Cytokine storm (CS) refers to the spontaneous dysregulated and hyper-activated
inflammatory reaction occurring in various clinical conditions, ranging from microbial …

Acute infections cause local and systemic disorders which can lead in the most severe forms
to multi-organ failure and eventually to death. The host response to infection encompasses a …

The COVID-19 pandemic has been a challenge to propose efficient therapies. Because
severe SARS-CoV2 infection is a viral sepsis eventually followed by an immunological …

Mental disorders such as anxiety, depression, and memory loss have been described in
patients with chronic Chagas disease (CD), a neglected tropical disease caused by the …

目的: 探讨不同剂量栀子苷治疗脓毒症的疗效和主要生物学机制. 方法: 雄性BALB/c
小鼠通过盲肠结扎穿孔技术(cecalligationandpuncture, CLP) 复制脓毒症模型. 在生存实验中 …

Revisiting Metchnikoff's work in light of the COVID-19 pandemic illustrates how much this
amazing scientist was a polymath, and one could speculate how much he would have been …

The human innate and adaptive immune system consists of effector cells producing
cytokines, interleukins, interferons, chemokines, and numerous other mediators. Usually, a …

We appreciate the letter by Honore et al. and agree with their example that similar to
cytokine levels, endotoxin levels may not be representative of the associated toxicity. It is …