In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

N Suga, Y Ikeda, S Yoshikawa, K Taniguchi… - Neurology …, 2023 - mdpi.com
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved
in the development of multiple diseases, which might be a prevalent modification of …

Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance …

M Ye, J Chen, F Lu, M Zhao, S Wu, C Hu, P Yu, J Kan… - Cell & Bioscience, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most abundant
reversible methylation modification in eukaryotes, and it is reportedly closely associated with …

Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease

WS Lian, RW Wu, YH Lin, YS Chen, H Jahr, FS Wang - Antioxidants, 2024 - mdpi.com
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates
the development of osteoporosis, which is the leading risk factor of disability in the elderly …

[HTML][HTML] PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer

L Liu, L Li, W Zu, J Jing, G Liu, T Sun, Q Xie - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Cervical cancer (CC) is one of the leading cancers among the female reproductive system.
The piwi-interacting RNA (piRNA) function and biogenesis has been studied in various …

[HTML][HTML] ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m6A-dependent …

H Wang, S Zhao, H Liu, Y Liu, Z Zhang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Background: N6-methyladenosine (m 6 A) is the most common and abundant mRNA
modification, playing an essential role in biological processes and tumor development …

M6A regulator methylation patterns and characteristics of immunity in acute ST-segment elevation myocardial infarction

J Yang, Q Shangguan, G Xie, M Yang, G Sheng - Scientific Reports, 2023 - nature.com
M6A methylation is the most prevalent and abundant RNA modification in mammals.
Although there are many studies on the regulatory role of m6A methylation in the immune …

[HTML][HTML] ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis

T Zhang, S Zhu, GW Huang - World Journal of Gastroenterology, 2024 - ncbi.nlm.nih.gov
BACKGROUND Increasing evidence has demonstrated that N6-methyladenosine (m 6 A)
RNA modification plays an essential role in a wide range of pathological conditions …

Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss

M Feng, X Zhou, Y Hu, J Zhang, T Yang, Z Chen… - Biomolecules, 2023 - mdpi.com
Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common
neurodegenerative disorders in elderly individuals and has a prevalence of approximately …

N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4

C Zhang, Y Cui - Biological Chemistry, 2024 - degruyter.com
Abstract N6-methyladenosine (m6A) and N7-methylguanosine (m7G) modification of RNA
represent two major intracellular post-transcriptional regulation modes of gene expression …

[HTML][HTML] Hydroxychloroquine modulates M6A RNA methylation in prostate cancer cells

S Yanar, MGB Albayrak - Cumhuriyet Science Journal, 2023 - csj.cumhuriyet.edu.tr
Prostate cancer ranks as the second most prevalent cancer in men globally. One of the
evolving subjects of investigation in prostate cancer is the role of N6-methyladenosine …