Thanks to advances in modern medicine over the past century, the world's population has
experienced a marked increase in longevity. However, disparities exist that lead to groups …

A frailty index (FI) based on clinical deficit accumulation (FI-Clinical) quantifies frailty in
aging mice. We aimed to develop a laboratory test-based murine FI tool (FI-Lab) and to …

The development of animal models to study human frailty is important to test interventions to
be translated to the clinical practice. The aim of this work was to develop a score for frailty in …

On average, aging is associated with unfavorable changes in cellular metabolism, which are
the processes involved in the storage and expenditure of energy. However, metabolic …

Therapies targeted at fundamental processes of aging may hold great promise for
enhancing the health of a wide population by delaying or preventing a range of age-related …

Highlights•Sex is underrepresented in most aspects of rodent research.•Additional cost and
perceived variability in females often excludes them from research.•Many believe incorrectly …

Frailty is defined as a decline in an organism's physiological reserves resulting in increased
vulnerability to stressors. In humans, a single continuous variable, the so-called Frailty Index …

Low‐protein (LP) diets are associated with a decreased risk of diabetes in humans, and
promote leanness and glycaemic control in both rodents and humans. While the effects of an …

To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the
morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as …

Calorie restriction without malnutrition increases longevity and delays the onset of age-
associated disorders in multiple species. Recently, greater emphasis has been placed on …