Activation of SIRT1 has previously been shown to protect mice against osteoporosis through
yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator …

Many age-related biochemical, physiological and behavioral changes are known to be sex-
specific. However, how sex influences frailty status and mortality risk in frail rodents has yet …

Mouse models of Alzheimer's disease (AD) exhibit marked differences in life expectancy
depending on their genotype and sex. The assessment of frailty could provide a measure of …

OBJECTIVE To define a frailty-related phenotype—a clinical syndrome associated with the
aging process in humans—in aged dogs and to investigate its association with time to death …

With an increasing aging population, the burden of age-related diseases magnifies. To
alleviate this burden, geroprotection has been an area of intense research focus with the …

The proportion of the population over the age of 65 is growing the most rapidly due to the
longevity revolution. Frailty is prevalent in this age group and strongly associated with …

Aims To investigate whether transient dietary restriction or aerobic exercise in young
adulthood exert long-lasting protection against brain aging later in life. Main methods Seven …

Methionine restriction (MR) extends lifespan in various model organisms, and
understanding the molecular effectors of MR could expand the repertoire of tools targeting …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Introduction: The number of people with dementia internationally is increasing. Older adults
with dementia are prescribed multiple medications, both to treat dementia symptoms and to …