Human life expectancy has increased dramatically in the last century and as a result also the
prevalence of a variety of age-related diseases and syndromes. One such syndrome is …

Frailty is a clinical geriatric syndrome characterized by decreased multisystem function and
increased vulnerability to adverse outcomes. Although numerous studies have been …

Frailty is an age-related condition characterized by a multisystem functional decline,
increased vulnerability to stressors, and adverse health outcomes. Quantifying the degree of …

Use of different objective frailty assessment tools may improve understanding of the biology
of frailty and allow evaluation of effects of interventions on frailty. Polypharmacy is …

Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in most
species. There is growing evidence that the gut microbiota has a pivotal role in host health …

Although animal models have helped to elaborate meaningful hypotheses about the
pathophysiology of sudden and unexpected death in epilepsy (SUDEP), specific prevention …

Senescent cells may have a prominent role in driving inflammation and frailty. The impact of
cellular senescence on frailty varies depending on the assessment tool used, as it is …

Frailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and
stress of the internal environment, which simultaneously increases the risk of adverse health …

Background Frailty is a major age‐associated syndrome leading to disability. Oxidative
damage plays a significant role in the promotion of frailty. The cellular antioxidant system …

An understanding of early-onset mechanisms underlying age-related changes can be
obtained by evaluating changes that precede frailty and end of life using histological …