[HTML][HTML] Molecular pathogenesis of fibrosis, thrombosis and surfactant dysfunction in the lungs of severe COVID-19 patients

A Krygier, D Szmajda-Krygier, R Świechowski… - Biomolecules, 2022 - mdpi.com
The global scope and scale of the SARS-CoV-2 pandemic led to huge amounts of important
data from clinical observations and experimental analyses being collected, in particular …

[HTML][HTML] Evaluation of the interaction between tumor growth factor-β and interferon type I pathways in patients with COVID-19: focusing on ages 1 to 90 years

M Abbasifard, AH Fakhrabadi, F Bahremand… - BMC Infectious …, 2023 - Springer
Background Evidence revealed that age could affect immune responses in patients with the
acute respiratory syndrome of coronavirus 2 (SARS-CoV-2) infection. This study investigated …

Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection

HW Barnes, S Demirdjian, NL Haddock, G Kaber… - Matrix Biology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged as the
cause of a global pandemic. Infection with SARS-CoV-2 can result in COVID-19 with both …

[HTML][HTML] COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

N de Souza Xavier Costa, G Ribeiro Júnior… - Respiratory …, 2023 - Springer
Background Lung fibrosis is a major concern in severe COVID-19 patients undergoing
mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly …

[HTML][HTML] TGF Beta as a Prognostic Biomarker of COVID-19 Severity in Patients with NAFLD—A Prospective Case–Control Study

F Susak, N Vrsaljko, A Vince, N Papic - Microorganisms, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease in
Western countries, has been identified as a possible risk factor for COVID-19 severity …

The role of cytokines and Molecular pathways in Lung Fibrosis following SARS-CoV-2 infection: a physiopathologic (re) view

M Lazar, M Sandulescu, EC Barbu, CE Chitu-Tisu… - Biomedicines, 2024 - mdpi.com
SARS-CoV-2 infection is a significant health concern that needs to be addressed not only
during the initial phase of infection but also after hospitalization. This is the consequence of …

Network-based analysis between SARS-CoV-2 receptor ACE2 and common host factors in COVID-19 and asthma: Potential mechanistic insights

Q Yan, XY Lin, CW Peng, WJ Zheng, XH Liu… - … Signal Processing and …, 2024 - Elsevier
ACE2 as a functional receptor for SARS coronavirus plays an important role in COVID-19
infection of the host. Thus, we aimed to explore interaction networks between ACE2 and …

[PDF][PDF] Host and microbiome features of secondary infections in lethal covid-19

M Zacharias, K Kashofer, P Wurm, P Regitnig… - IScience, 2022 - cell.com
Secondary infections contribute significantly to covid-19 mortality but driving factors remain
poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic …

[HTML][HTML] The “Elastic Perspective” of SARS-CoV-2 infection and the role of intrinsic and extrinsic factors

F Boraldi, FD Lofaro, A Cossarizza… - International Journal of …, 2022 - mdpi.com
Elastin represents the structural component of the extracellular matrix providing elastic recoil
to tissues such as skin, blood vessels and lungs. Elastogenic cells secrete soluble …

[HTML][HTML] Immune response gaps linked to SARS-CoV-2 infection: cellular exhaustion, senescence, or both?

LV Barbosa, DMM Prá, S Nagashima… - International Journal of …, 2022 - mdpi.com
The COVID-19 pandemic, promoted by the SARS-CoV-2 respiratory virus, has resulted in
widespread global morbidity and mortality. The immune response against this pathogen has …