SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
[HTML][HTML] Recent developments in molecular modeling tools and applications related to pharmaceutical and biomedical research
P Peluso, B Chankvetadze - Journal of Pharmaceutical and Biomedical …, 2023 - Elsevier
In modern pharmaceutical and biomedical research, molecular modeling represents a
useful tool to explore processes and their mechanistic bases at the molecular level …
useful tool to explore processes and their mechanistic bases at the molecular level …
In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection
Presently, there are no approved drugs or vaccines to treat COVID-19, which has spread to
over 200 countries and at the time of writing was responsible for over 650,000 deaths …
over 200 countries and at the time of writing was responsible for over 650,000 deaths …
[HTML][HTML] An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: promises and challenges
X Xu, Y Chen, X Lu, W Zhang, W Fang, L Yuan… - Biochemical …, 2022 - Elsevier
The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19
pandemic, bring new waves of infection worldwide. Identification of effective therapeutic …
pandemic, bring new waves of infection worldwide. Identification of effective therapeutic …
Revealing the inhibition mechanism of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by remdesivir and nucleotide analogues: A molecular dynamics …
PD Wakchaure, S Ghosh… - The Journal of Physical …, 2020 - ACS Publications
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
Synthesis, spectroscopic (FT-IR, FT-Raman, NMR & UV-Vis), reactive (ELF, LOL, Fukui), drug likeness and molecular docking insights on novel 4-[3-(3-methoxy …
The spectroscopic analysis such as FT-IR, FT-Raman, UV-Vis and NMR are conducted for
the synthesized molecule by both experimental and theoretical approach. The theoretical …
the synthesized molecule by both experimental and theoretical approach. The theoretical …
Identification of probable inhibitors for the DNA polymerase of the Monkeypox virus through the virtual screening approach
Given the paucity of antiviral treatments for monkeypox disease, caused by the Monkeypox
virus (MPXV), there is a pressing need for the development/identification of new drugs to …
virus (MPXV), there is a pressing need for the development/identification of new drugs to …
Repurposing of gastric cancer drugs against COVID-19
Abstract Corona Virus Disease 2019 (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) has become a global pandemic. Additionally, the …
Syndrome Coronavirus 2 (SARS-CoV-2) has become a global pandemic. Additionally, the …
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
LV Yevsieieva, KO Lohachova, A Kyrychenko… - RSC …, 2023 - pubs.rsc.org
The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
In Silico Exploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp
K Pandey, KB Lokhande, KV Swamy… - … and Biology Insights, 2021 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has increased
the importance of computational tools to design a drug or vaccine in reduced time with …
the importance of computational tools to design a drug or vaccine in reduced time with …