The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

When the non-coding repeat expansion in the C9ORF72 gene was discovered to be the
most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlapping clinically with type I IFN-mediated disease due to gain-of-function in STING, a …

Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-
AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the …

The small GTPase ARL8 associates with endolysosomes, leading to the recruitment of
several effectors that couple endolysosomes to kinesins for anterograde transport along …

ADP-ribosylation factor (ARF) GTPases are major regulators of cellular membrane
homeostasis. High sequence similarity and multiple, possibly redundant functions of the five …

COPI‐coated vesicles mediate transport between Golgi stacks and retrograde transport from
the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric …

Molecular switches of the ADP-ribosylation factor (ARF) GTPase family coordinate
intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi …

Mutation of C9orf72 is the most prevalent defect associated with amyotrophic lateral
sclerosis and frontotemporal degeneration. Together with hexanucleotide-repeat …

The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …