Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

It has been suggested that highly social mammals, such as naked mole rats and humans,
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …

Use of model organisms in aging research is problematic because our ability to extrapolate
across the tree of life is not clear. On one hand, there are conserved pathways that regulate …

The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …

Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to
underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum …

Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

The exceptional longevity of social insect queens despite their lifelong high fecundity
remains poorly understood in ageing biology. To gain insights into the mechanisms that …

New Findings What is the topic of this review? The reasons for the continuing increase in
human life expectancy are examined in the light of progress in understanding the …

The circadian clock coordinates the daily cyclic rhythm of numerous biological processes by
regulating a large portion of the transcriptome. In animals, the circadian clock is involved in …