The hypocretin/orexin system mediates the extinction of fear memories
Anxiety disorders are often associated with an inability to extinguish learned fear responses.
The hypocretin/orexin system is involved in the regulation of emotional states and could also …
The hypocretin/orexin system is involved in the regulation of emotional states and could also …
FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence
PA Spagnolo, VA Ramchandani… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Background A common single nucleotide polymorphism (C385A) in the human fatty acid
amide hydrolase (FAAH) gene has been associated with decreased distress responses in …
amide hydrolase (FAAH) gene has been associated with decreased distress responses in …
The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial
Acute pharmacological inhibition of the anandamide-degrading enzyme, fatty acid amide
hydrolase (FAAH), prolongs the regulatory effects of endocannabinoids and reverses the …
hydrolase (FAAH), prolongs the regulatory effects of endocannabinoids and reverses the …
Cannabinoid interventions for PTSD: Where to next?
Cannabinoids are a promising method for pharmacological treatment of post-traumatic
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …
Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses
Accumulating evidence over the past decade has highlighted an important role of the
endocannabinoid (eCB) system in the regulation of stress and emotional behavior across …
endocannabinoid (eCB) system in the regulation of stress and emotional behavior across …
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain …
Traumatic brain injury (TBI) is the leading cause of death in young adults in the United
States, but there is still no effective agent for treatment. N-arachidonoylethanolamine …
States, but there is still no effective agent for treatment. N-arachidonoylethanolamine …
Upregulation of anandamide hydrolysis in the basolateral complex of amygdala reduces fear memory expression and indices of stress and anxiety
Increased anandamide (AEA) signaling through inhibition of its catabolic enzyme fatty acid
amide hydrolase (FAAH) in the basolateral complex of amygdala (BLA) is thought to buffer …
amide hydrolase (FAAH) in the basolateral complex of amygdala (BLA) is thought to buffer …
Endocannabinoid signaling regulates sleep stability
MJ Pava, A Makriyannis, DM Lovinger - PLoS One, 2016 - journals.plos.org
The hypnogenic properties of cannabis have been recognized for centuries, but
endogenous cannabinoid (endocannabinoid) regulation of vigilance states is poorly …
endogenous cannabinoid (endocannabinoid) regulation of vigilance states is poorly …
Exercise-induced increases in Anandamide and BDNF during extinction consolidation contribute to reduced threat following reinstatement: Preliminary evidence from …
KM Crombie, A Sartin-Tarm, K Sellnow… - …, 2021 - Elsevier
Introduction We recently demonstrated that moderate-intensity aerobic exercise delivered
during the consolidation of fear extinction learning reduced threat expectancy during a test …
during the consolidation of fear extinction learning reduced threat expectancy during a test …
The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease
Fatty acid amide hydrolase (FAAH) is a prominent enzyme of the endocannabinoid system
that degrades endogenous cannabinoid anandamide and oleamide. These lipid amides are …
that degrades endogenous cannabinoid anandamide and oleamide. These lipid amides are …