Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …

Background: It has been suggested that the metabolic benefits of physical exercise could be
mediated by myokines. We examined here the effect of exercise training on skeletal muscle …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

Exercise, in the form of endurance or resistance training, leads to specific molecular and
cellular adaptions not only in skeletal muscles, but also in many other organs such as the …

The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors
(GPCRs) and is involved in range of physiological and pathological functions, including fluid …

Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in
mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …