Nose-to-brain delivery of therapeutic peptides as nasal aerosols
Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration,
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …
Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis
A Mwema, GG Muccioli, A Des Rieux - Journal of Controlled Release, 2023 - Elsevier
Disorders of the central nervous system (CNS), such as multiple sclerosis (MS) represent a
great emotional, financial and social burden. Despite intense efforts, great unmet medical …
great emotional, financial and social burden. Despite intense efforts, great unmet medical …
[HTML][HTML] Non-invasive strategies for nose-to-brain drug delivery
Intranasal drug administration is a promising method for delivering drugs directly to the
brain. Animal studies have described pathways and potential brain targets, but nose-to-brain …
brain. Animal studies have described pathways and potential brain targets, but nose-to-brain …
Numerical study of the effect of nasopharynx airway obstruction on the transport and deposition of nanoparticles in nasal airways
Although there is abundant literature for both experimental and numerical studies of
respiratory aerosol exposure in nasal airways, research efforts concentrating on diseased …
respiratory aerosol exposure in nasal airways, research efforts concentrating on diseased …
Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity
Intranasal drug delivery has attracted significant attention because of the opportunity to
deliver systemic drugs directly to the blood stream. However, the mucociliary clearance …
deliver systemic drugs directly to the blood stream. However, the mucociliary clearance …
Effect of different degrees of adenoid hypertrophy on pediatric upper airway aerodynamics: a computational fluid dynamics study
Z Hu, J Dong, M Lou, J Zhang, R Ma, Y Wang… - … and Modeling in …, 2023 - Springer
To improve the diagnostic accuracy of adenoid hypertrophy (AH) in children and prevent
further complications in time, it is important to study and quantify the effects of different …
further complications in time, it is important to study and quantify the effects of different …
Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application
Y Liu, D Wu - Laryngoscope Investigative Otolaryngology, 2023 - Wiley Online Library
Objectives To compare the deposition patterns within the nasal cavity between the bi‐
directional and unilateral nasal delivery systems. And to summarize the clinical application …
directional and unilateral nasal delivery systems. And to summarize the clinical application …
Olfactory targeting of microparticles through inhalation and bi-directional airflow: effect of particle size and nasal anatomy
Background: Targeting drugs to the olfactory region in the nasal cavity can bypass the
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
Organic solution advanced spray-dried microparticulate/nanoparticulate dry powders of lactomorphin for respiratory delivery: Physicochemical characterization, in vitro …
The purpose of this study was to formulate Lactomorphin (MMP2200) in its pure state as
spray-dried (SD) powders, and with the excipient Trehalose as co-spray-dried (co-SD) …
spray-dried (SD) powders, and with the excipient Trehalose as co-spray-dried (co-SD) …
Detailed comparative analysis of environmental microparticle deposition characteristics between human and monkey nasal cavities using a surface mapping …
Inhaled particulate matter is associated with nasal diseases such as allergic rhinitis,
rhinosinusitis and neural disorders. Its health risks on humans are usually evaluated by …
rhinosinusitis and neural disorders. Its health risks on humans are usually evaluated by …