Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence

GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …

Not just antibodies: B cells and T cells mediate immunity to COVID-19

RJ Cox, KA Brokstad - Nature Reviews Immunology, 2020 - nature.com
Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following
recovery from the virus have caused alarm. However, the absence of specific antibodies in …

[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

A Sokal, P Chappert, G Barba-Spaeth, A Roeser… - Cell, 2021 - cell.com
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …

SARS-CoV-2 mRNA vaccines: immunological mechanism and beyond

E Bettini, M Locci - Vaccines, 2021 - mdpi.com
To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive
immunity, including B and T cell responses. While B cell responses are key, as they can …

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

WN Voss, YJ Hou, NV Johnson, G Delidakis, JE Kim… - Science, 2021 - science.org
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies
that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS …

Obesity: a critical risk factor in the COVID‐19 pandemic

S Kwok, S Adam, JH Ho, Z Iqbal, P Turkington… - Clinical …, 2020 - Wiley Online Library
Obesity is an emerging independent risk factor for susceptibility to and severity of
coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome …

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?

G Milne, T Hames, C Scotton, N Gent… - The Lancet …, 2021 - thelancet.com
Many nations are pursuing the rollout of SARS-CoV-2 vaccines as an exit strategy from
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …

Immunity to SARS‐CoV‐2 induced by infection or vaccination

X Castro Dopico, S Ols, K Loré… - Journal of internal …, 2022 - Wiley Online Library
Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …

Learning from the past: development of safe and effective COVID-19 vaccines

S Su, L Du, S Jiang - Nature Reviews Microbiology, 2021 - nature.com
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
elicited an equally rapid response aiming to develop a COVID-19 vaccine. These efforts are …

Count on us: T cells in SARS-CoV-2 infection and vaccination

K Kedzierska, PG Thomas - Cell Reports Medicine, 2022 - cell.com
Robust T cell responses have been associated with milder outcomes in many infections. T
cells also establish long-term memory pools and, as they are predominantly directed toward …