Progress and promise of genome-wide association studies for human complex trait genetics
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …
There has been early success for prevalent diseases with complex phenotypes. These …
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
T Sigurdsson, KL Stark, M Karayiorgou, JA Gogos… - Nature, 2010 - nature.com
Abnormalities in functional connectivity between brain areas have been postulated as an
important pathophysiological mechanism underlying schizophrenia,. In particular …
important pathophysiological mechanism underlying schizophrenia,. In particular …
Whole-genome resequencing of 292 pigeonpea accessions identifies genomic regions associated with domestication and agronomic traits
Pigeonpea (Cajanus cajan), a tropical grain legume with low input requirements, is
expected to continue to have an important role in supplying food and nutritional security in …
expected to continue to have an important role in supplying food and nutritional security in …
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Heart Attack Risk in Puget Sound. Schwartz Stephen … - Nature …, 2009 - nature.com
We conducted a genome-wide association study testing single nucleotide polymorphisms
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …
The Kraepelinian dichotomy–going, going… but still not gone
N Craddock, MJ Owen - The British Journal of Psychiatry, 2010 - cambridge.org
Recent genetic studies reinforce the view that current approaches to the diagnosis and
classification of major psychiatric illness are inadequate. These findings challenge the …
classification of major psychiatric illness are inadequate. These findings challenge the …
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nature, 2010 - nature.com
Copy number variants (CNVs) account for a major proportion of human genetic
polymorphism and have been predicted to have an important role in genetic susceptibility to …
polymorphism and have been predicted to have an important role in genetic susceptibility to …
Rare chromosomal deletions and duplications increase risk of schizophrenia
Cardiff University O'Donovan Michael C. 5 Kirov … - Nature, 2008 - nature.com
Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive
deficits and apathy, with a heritability estimated at 73–90%(ref.). Inheritance patterns are …
deficits and apathy, with a heritability estimated at 73–90%(ref.). Inheritance patterns are …
Structure and control of the actin regulatory WAVE complex
Abstract Members of the Wiskott–Aldrich syndrome protein (WASP) family control
cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The …
cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The …
[HTML][HTML] Rare variants create synthetic genome-wide associations
Genome-wide association studies (GWAS) have now identified at least 2,000 common
variants that appear associated with common diseases or related traits (http://www. genome …
variants that appear associated with common diseases or related traits (http://www. genome …
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
E Taoufik, G Kouroupi, O Zygogianni… - Open …, 2018 - royalsocietypublishing.org
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …
synapse structure and function, and can be either the cause or the consequence in specific …