• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to
genetic alterations, but identifying the genes responsible has proved challenging …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …

Human diseases are caused by alleles that encompass the full range of variant types, from
single-nucleotide changes to copy-number variants, and these variations span a broad …

Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral
and emotional processes. The wide spectrum of symptoms and clinical variability in …

Neurodevelopmental disorders can be caused by many different genetic abnormalities that
are individually rare but collectively common. Specific genetic causes, including certain copy …

Abstract Chromosome region 1q21. 1 contains extensive and complex low-copy repeats,
and copy number variants (CNVs) in this region have recently been reported in association …

Intellectual disability (ID) is the leading socio-economic problem of health care, but
compared to autism and schizophrenia, it has received very little public attention. Important …

MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the
superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant …

Uncertainty about the phase of strings of SNPs creates complications in genetic analysis,
although methods have been developed for phasing population-based samples. However …