Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study
the acute impact of psychedelics on the human brain. While fMRI is a promising tool for …

How rapid-acting antidepressants (RAADs), such as ketamine, induce immediate and
sustained improvements in mood in patients with major depressive disorder (MDD) is poorly …

This review article presents select recent studies that form the basis for the development of
esmethadone into a potential new drug. Esmethadone is a promising member of the …

The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in
several studies. However, the molecular mechanisms involved in these actions remain …

Postpartum depression (PPD) is a common major depressive episode surrounding
childbirth, with estimated rates ranging from 5.5% to 23.5% of all live births across Europe …

The glutamate N-methyl-d-aspartate receptor antagonist ketamine has a rapid
antidepressant effect. Despite large research efforts, ketamine's mechanism of action in …

Background Agomelatine has been shown to be effective in the treatment of depression, but
the molecular mechanisms underlying its antidepressant effects have yet to be elucidated …

Major depressive disorder (MDD) is a complex and common disorder, with many factors
involved in its onset and development. The clinical management of this condition is …

Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …

Depression in older adults with cognitive impairment increases progression to dementia.
Microbiota is associated with current mood and cognition, but the extent to which it predicts …