Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze
the transamination reactions between amino acid donor and keto acid acceptor substrates …

Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

The nucleotide ppGpp is a highly conserved regulatory molecule in bacteria that helps tune
growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth …

Substrate channeling is the process of direct transfer of an intermediate between the active
sites of two enzymes that catalyze sequential reactions in a biosynthetic pathway (for …

▪ Abstract The three-dimensional structures of tryptophan synthase, carbamoyl phosphate
synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, and asparagine …

Purine biosynthesis requires ten enzymatic transformations to generate inosine
monophosphate. PurF, PurD, PurL, PurM, PurC, and PurB are common to all pathways …

Outlining the fundamental principles by which all interactions occur, this reference focuses
on harnessing the biochemistry of bioorganic compounds in order to separate them …

Multiwavelength anomalous diffraction (MAD) has been used to determine the structure of
the regulatory enzyme of de novo synthesis of purine nucleotides, glutamine 5 …

Enzymes utilizing glutamine as an amide donor. Page 105 ENZYMES UTILIZING
GLUTAMINE AS AN AMIDE DONOR By HOWARD ZALKIN, Professor of Biochemistry …

Glutamine-dependent amidotransferases have been known for more than 30 years. The
mechanism by which these enzymes generate ammonia from the glutamine amide nitrogen …